Chemical Constituents and Components :Main chemical constituents are phyllanthine, hypophyllanthine, alkaloids, quercetin, quercertrin, isoquercitrin, astragalin, amarin, geraniin, corilagin, rutin and 3-O-glucopyranoside.

Action :
Bitters: 1. It blocks DNA polymerase, an enzyme required by Hepatitis B virus for growth and replication. 2. It inhibits lipid peroxidation and scavenges hydroxyl and superoxide radicals in vitro. 3. It shows inhibiting properties on both COX-2 and inducible nitric oxide synthase (iNOS). 4. It plays important role in the disruption of HbsAg mRNA transcription and post-transcription which is beneficial against viral carcinogenesis. 5. It shows the antagonistic effect on calcium channel and blocks voltage-dependent Ca++ currents. 6. It significantly reduces the plasma activities of alanine and aspartate transaminases and total bilirubin concentration.

Curing Diseases:1. It is diuretic, hypotensive and hypoglycemic in nature.
2. It is very useful against chronic and acute Hepatitis B.
3. It is used to cure jaundice, gonorrhea and diabetes.
4. It is used in sores, swelling and itchiness.
5. It is also used in frequent menstruation.
6. It is useful in ophthalmia and chronic dysentery.
7. It promotes liver functions and helpful to cure liver related problems.

Research Information:P Phyllanthus amarus is a potential diuretic, hypotensive and hypoglycaemic drug for humans. (Ref. To study the diuretic, hypotensive and hypoglycaemic effects of Phyllanthus amarus, Indian J Experimental Biology1995; 33(11): 861-864)

Possible Combinations :P Phyllanthus amarus + phyllanthus niruri (very effective against hepatitis b)